Endocrine Abstracts

A 46 year old female presented with 12 months history of secondary amenorrhoea. Prolactin was 4746 mIU/l without macroprolactin complexes, LH & FSH were low, oestradiol was undetectable. She had normal visual fields. No other clinical or biochemical features of pituitary dysfunction. She had no regular medication. Pituitary MRI was normal. She was started on cabergoline 250 mcg twice weekly which was subsequently increased to 500 mcg twice weekly. Repeat serum prolactin 5 ...

Clinical case: A 30-year-old Eritrean presented as an emergency to the orthopaedics surgeons with radicular back pain. Following L3/L4 spinal decompression, he was noted to be classically acromegaloid and was transferred to the Endocrine Unit, where a mild bitemporal upper quadrantinopia was noted. GH was massively elevated at 1200 mU/L, IGF1>130 nmol/L, with associated corticotroph and gonadotroph insufficiencies requiring replacement. MRI showed a large pituitary adenoma...

Backround: Androgenic anabolic steroids (AAS) are reported to increase cardiovascular risk by causing adverse changes in lipid profiles, impaired glucose tolerance, hyperhomocystinaemia and hypertension. Recent studies have also suggested impaired vascular reactivity in this group.Aim: To assess cardiovascular risk factors and arterial stiffness in AAS using and non-steroid using male bodybuilders and to compare them with healthy controls.Methods: Studies were conducte...